Marmaduke is very concerned that his Owner-Girl is using makeup at such a young age.

Or perhaps he's worried that it will make the meat taste funny. It's hard to tell with Marmaduke.

Marmaduke's Owner-Girl and her friend delight in making the other denizens of the void drink lemonade tainted with dog saliva.

Marmaduke's Owner-Girl does not have the appropriate amount of fear for Marmaduke. Her friend does.

Marmaduke is pretending to sulk in his doghouse but no one can know what horrors he's really conjuring.

Marmaduke is stronger than several small children because he's bigger than the average dog.

Marmaduke appears to be missing his midsection. For a normal dog this would be a grave concern but for Marmaduke it's just another day.

Marmaduke is using his telekinesis irresponsibly.

Marmaduke's Owner-Man is very confused about the kinds of tricks Marmaduke can perform. Rather than 'sit' or 'fetch', Marmaduke excels at 'murder' and 'destroying the souls of those around him'.

Marmaduke has lost a great amount of mass.

Marmaduke seems to have broken his Owner-Man's hip. Next, Marmaduke will break his very essence.

Marmaduke has died and his Owner-Family is very obtuse.

Marmaduke has slyly put his X-rated movies in regular movie cases.

Marmaduke has telekinetic powers but instead of using them for good or evil he uses them for dental hygiene.

Anyone else find it weird that there were consecutive "jokes" about minty dog breath?

I keep trying to think of something to write but Marmaduke's Owner-Lady's shapely ass is distracting me.

Marmaduke's Neighbor-Man is a disgusting pervert.

Marmaduke was the inspiration for Kirby but instead of a dreamland, Marmaduke has created a nightmarish dystopia to rule over.

It seems that the Andersons don't know what donuts look like. If it was just the special one I could just say something like "These brave souls are trying to poison Marmaduke to free the town of his horrible reign" but the sign clearly says "DONUTS" and the background is full of what is obviously loaves of bread.

Marmaduke is driving his Neighbor-People to the brink of madness for daring to challenge his knowledge.

Marmduke's Owner-Man got a little caught up in the role-playing.

Marmaduke lives in a real shitty town I guess.

I have no clue what the hell the caption has to do with the cartoon.

Marmaduke's Neighbor-Man has started to eat himself in an attempt to escape Marmaduke's reign of terror. It will not work.